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Pharmaceuticals from Furfural

Furfural is also a building block for compounds applied as pharmaceuticals, as insecticides, as microbicides, as fungicides, and for special polymers.

Example:

(2S)-phenyl-3-piperidone is an intermediate in the synthesis of compounds, which possess pharmacological activit. A group of researchers published in May 2014 their "efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps with 54% yield from biomass derived furfural" [1]. The starting material for the synthesis was sun-dried rice straw, which was "collected from a rice straw farm in Jiangxi Province Fengcheng Area (China).

While at present the principal applications of furfural are seen to be as an extractant for lubricating oils, vegetable oils, and diesel fuel, as a fungicide, as a nematocide, and as the raw material for furfuryl alcohol to make foundry resins, other uses have been proven successfully on a multitude of fronts, and it is only a lack of research which prevents furfural and its derivatives from flooding the world in a stunning variety of different applications.[2]

Also see:

Other articles on dalinyebo.com that are related to 'Pharma'

Green Chemical Building Block

Map to Furfural and its many By-Products

Furfural and its many By-products

References:

[1] Teck Peng Loh, Peng-Fei Koh, Peng Wang and Jing-Mei Huang,  Biomass Derived Furfural-Based Facile Synthesis of Protected (2S)-phenyl-3-piperidone, a Common Intermediate for Many Drugs, Chem. Commun., 2014, Accepted Manuscript (Supporting information, for our clients: downloads)

[2] Introduction to the last chapter ("Odd Applications") of the appendices in Karl Joachim ZeitschThe Chemistry and Technology of Furfural and its Many By-Products; Sugar Series, Vol. 13; Elsevier: Amsterdam, 2000.

Since 2001, DalinYebo provides knowhow:

To convert biomass to value added chemical products and applications that are used in industries such as steel, wood, pharmaceutical, automotive, agricultural chemicals, industrial chemicals, etc.

For the agri (biomass) processing, sugar, pulp&paper, etc. industries, we provide knowhow and technology to convert (residual) biomass to chemicals and energy.

For owners of biomass we offer technology and market access, creating investment opportunities in the cleantech space.

The essential technical challenge facing us, and the world in general, is the complete beneficiation of cellulosic material. We strive to provide viable and practical solution. Contact us to discuss the economic potential of your biomass.
  • Furfural
  • Furfural and its many Byproducts
  • pharmaceutical...
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The only sustainable alternative to tropical hardwood

Furfuryl alcohol, which is made from bio-renewable furfural, is the main ingredient used for wood-modification processes like 'kebonisation', which convert softwoods in looks and properties that are similar to tropical hardwood. Originally designed to replace the toxic CCA process, furfurylation of wood offers non-toxic woods for playgrounds, floors, cladding, etc.

from Kebony.com: Developed in Norway, the Kebony technology is an environmentally friendly patented process, which enhances the properties of non-durable softwoods with a bio-based liquid.

As a result the wood’s cell structure is permanently modified adopting premium characteristics. Kebony is a highly durable, sustainable wood ..

.. with the aesthetics and performance of the best tropical hardwood, which requires minimum maintenance and brings low life cycle costs. Suitable for internal and external applications that demand high performance and great aesthetics, Kebony is available in clear and character grade pines. All Kebony woods acquire a silver patina after exposure to the elements.

Recognized as Technology Pioneer 2014 by the World Economic Forum and Global Cleantech Tech 100, Kebony has been embraced by leading architects and developers internationally, served through a global sales and distribution network.

Kebony: The New Wood

Also see:

Furfural and the Rainforest

New Green Materials

Eco-friendly High Quality Resins (Wood Glues)

Furfurly Alcohol

Since 2001, DalinYebo provides knowhow:

To convert biomass to value added chemical products and applications that are used in industries such as steel, wood, pharmaceutical, automotive, agricultural chemicals, industrial chemicals, etc.

For the agri (biomass) processing, sugar, pulp&paper, etc. industries, we provide knowhow and technology to convert (residual) biomass to chemicals and energy.

For owners of biomass we offer technology and market access, creating investment opportunities in the cleantech space.

The essential technical challenge facing us, and the world in general, is the complete beneficiation of cellulosic material. We strive to provide viable and practical solution. Contact us to discuss the economic potential of your biomass.
  • Wood
  • Furfuryl Alcohol...
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Overcoming the disadvantage of urea-formaldehyde treated wood

Furfural and urea react in an acid catalysed medium. The aldehyde group of furfural undergoes condensation with two urea and link the two urea substrate with the release of a water molecule to form a pure white furfural-urea resin (FUR).

A group of Indian scientists have developed an efficient synthesis of of untainted, superior furfural urea resin (FUR) [1]. Urea, a carbamide, is common organic chemical with versatile characteristics. It forms resins with aldehydes, most commonly formaldehyde, to produce urea-formaldehyde (UF) resins, which is used as a wood adhesive for many years, and is still the most widely used interior plywood and particleboard adhesive.

Urea is an attractive chemical for wood improvement because of its non-toxicity, cheapness and ease of use. However, formaldehyde-urea resins emit formaldehyde. Plywood interior furniture, or kitchen cupboards made from particle boards release formaldehyde, indoors! Formaldehyde is classified by the WHO as a known human carcinogen [2].

In order to reduce indoor formaldehyde levels, inferior glues with less formaldehyde have been used, since the 1980s, whilst research continued to find suitable alternatives.

The reaction of furfural and urea has been researched in the early 20th century. Until now, there were too many draw-backs to make it a viable process. This new synthesis, using a (natural!) zeolite catalyst, has eliminated them.

The new process claims the following:

Reduced reaction time.

Enhanced product quality.

The process is benign, environ friendly, efficient and extremely fast.

The natural zeolite catalyst can be recycled and reused, several times.

Reference:

[1] International Journal of Innovative Research in Science, Engineering and Technology (An ISO 3297: 2007 Certified Organization), Vol. 3, Issue 5, May 2014: Indian Natural Zeolites Catalyzed Urea Furfural Green Polymerization. (For our clients: Download publication and supporting information here)

[2] IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 88 (2006) Formaldehyde ..., WHO Press, 2006( English ).

Also see:

Furfuryl Alcohol: Turing Softwood into Hardwood

Furfural and the Rainforest

Furfurly Alcohol

New Green Materials

Since 2001, DalinYebo provides knowhow:

To convert biomass to value added chemical products and applications that are used in industries such as steel, wood, pharmaceutical, automotive, agricultural chemicals, industrial chemicals, etc.

For the agri (biomass) processing, sugar, pulp&paper, etc. industries, we provide knowhow and technology to convert (residual) biomass to chemicals and energy.

For owners of biomass we offer technology and market access, creating investment opportunities in the cleantech space.

The essential technical challenge facing us, and the world in general, is the complete beneficiation of cellulosic material. We strive to provide viable and practical solution. Contact us to discuss the economic potential of your biomass.
  • Furfural
  • Resins
  • Wood...
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Natural Fibres + Poly(Furfurly Alcohol)= Light weight structural panels

Poly(Furfuryl Alcohol), PFA, is obtained from a condensation polymerisation of furfuryl alcohol (FA). FA is made from furfural , which is manufactured from a variety of biomass.image Generic structure of PFA

Biomass-based furan resins are mainly known in the foundry industry. In addition, user-friendly furan resin systems have been developed for variety of composite applications [1]. Besides the use in the automotive industry, PFA composites have a high thermal stability and could also be used in interior of aircraft cabins, internal fittings for buildings, rail carriages or in the built environment [2].

Some fibre-reinforced PFA options:

Cellulosic fibre, e.g.: flax, hemp, sisal, bagasse or wood

Non-woven cellulose fibres

Carbon fibres or glass fibres

Mineral or graphite filler for use as a cementing binder for chemical resistant polymer concrete.

Eco-friendly thermo-stable bioresin:

PFA blended with lignin increases the biocomposite resin's strength[3]

References:

[1] Application of novel furan resins in composites, Dr. IR. Hans E. Hoydonckx, & Dr. IR. Wim M. Van Rhijn, Transfurans Chemical.

[2] Kumar, R and Anandjiwala, R. 2009. Flax reinforced thermoset composites from poly(furfuryl alcohol). 11th International Conference on Advanced Materials (ICAM). Rio de Janeiro, Brazil, 20-25 September 2009, pp 1-20

[3] image Macromolecular Materials and Engineering, Volume 299, Issue 5, pages 552–559, May 2014:  Renewable-Resource-Based Green Blends from Poly(furfuryl alcohol) Bioresin and Lignin.

Also see:

New Green Materials

Furfural By-products

Bioplastics

Connecting-The-Dots™

From Biomass to Value Added Products (Pharmaceutical, Ag-chemicals, Industrial Chemicals, etc.).

For the agri (biomass) processing, sugar, pulp&paper, etc. industries, we provide knowhow and technology to convert (residual) biomass to chemicals and energy.

For owners of biomass we offer technology and market access, creating investment opportunities in the cleantech space.

The essential technical challenge facing us, and the world in general, is the complete beneficiation of cellulosic material. We strive to provide viable and practical solution. Contact us to discuss the economic potential of your biomass.
  • Furfural and its many Byproducts
  • Furfuryl Alcohol
  • kenaf
  • Lignin
  • Poly(Furfuryl Alcohol)
  • Wood
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Synthesis of the Insecticide Prothrin from 5-(Chloromethyl)furfural (CMF)

J Agric Food Chem. 2014 Jan 3.[1]: Prothrin, a synthetic pyrethroid insecticide, was synthesized from the biomass-derived platform chemical 5-(chloromethyl)furfural in six steps and overall 65% yield. Two structural analogues of prothrin were also prepared following the same synthetic approach. Preliminary testing of these furan-based pyrethroids against the yellow fever mosquito Aedes Aegypti indicates promising insecticidal activities.

CMF is made in a one-step reaction under mild conditons from C6-sugars (e.g. D-fructose, D-glucose, sucrose etc.) or polysaccharides such as cellulose[2].

References:

[1] J Agric Food Chem. 2014 Jan 3

[2] Example: Highly efficient dehydration of carbohydrates to 5-(chloromethyl)furfural (CMF), 5-(hydroxymethyl)furfural (HMF) and levulinic acid by biphasic continuous flow processing, Green Chemistry, Issue 5, 2011 (For our clients: Download publication and supporting information here).

Also see:

Nematicides

Biomass to Pharmaceuticals

From Biomass to Medicines

Since 2001, DalinYebo provides knowhow:

To convert biomass to value added chemical products and applications that are used in industries such as steel, wood, pharmaceutical, automotive, agricultural chemicals, industrial chemicals, etc.

For the agri (biomass) processing, sugar, pulp&paper, etc. industries, we provide knowhow and technology to convert (residual) biomass to chemicals and energy.

For owners of biomass we offer technology and market access, creating investment opportunities in the cleantech space.

The essential technical challenge facing us, and the world in general, is the complete beneficiation of cellulosic material. We strive to provide viable and practical solution. Contact us to discuss the economic potential of your biomass.
  • Furan
  • insecticides
  • Furfural and its many Byproducts...
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