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Furan ring is an important pharmacophore in modern drug discovery

Furan, which is made from furfural, is a heterocyclic organic compound, consisting of a five-membered aromatic ring with four carbon atoms and one oxygen. The class of compounds containing such rings are also referred to as furans.

May 2014 - Asian J of Biosciences[1]: Furan a five membered heterocycles has been found with enormous biological activities with the suitable modifications in the structure. The present review is an attempt made to direct the attention of the researchers towards the Furan ring for the development of newer chemical entities. Which are quite useful in the treatment of various life threatening diseases and disorders? Along with the development in the various methods used for the environmentally benign synthesis of Furan with profound biological activities.

.. allow them to interact easily with the biopolymers, possess potential activity with lower toxicities in the chemotherapeutic approach in man.

Reference:

[1] Medworld-asia International Publishers, Asian J of Biosciences, May 2014 (1) 01, 07-14 (For our clients: Download here)

image Asian Journal of Biosciences is an open access, double blind peer revived, bimonthly journal dedicated for publication of high quality research work and unique findings in the field of Biosciences by Medworld - asia .

 

 

 

Also see:

Furfuryl Alginate: Useful for Wound Healing

Biomass to Pharmaceuticals

From Biomass to Medicines

Connecting-The-Dots™

From Biomass to Value Added Products (Pharmaceutical, Ag-chemicals, Industrial Chemicals, etc.)

For the agri (biomass) processing, sugar, pulp&paper, etc. industries, we provide knowhow and technology to convert (residual) biomass to chemicals and energy.

For owners of biomass we offer technology and market access, creating investment opportunities in the cleantech space.

The essential technical challenge facing us, and the world in general, is the complete beneficiation of cellulosic material. We strive to provide viable and practical solution. Contact us to discuss the economic potential of your biomass.
  • Furfural
  • Furan
  • medical
  • pharmaceutical...
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Why it is not Rocket Science: The Masterkey to the Furfural Business

We have previously reported on:

The Masterkey to the furfural business and 

Why the production of furfural is not Rocket Science.

In the presentation below, we showcase the last 12 projects with links to the summaries of our consulting activities (business plans, feasibility studies, concept plans, project development plans, etc.)

Related Sites

Connecting-The-Dots™ (Creating Biobased Businesses: About our experience to connect the many "dots" of the value chains that every successful biobased business needs)

µ-BioRefinery™ (in propinquitatem ad biomasa; Bringing biorefining in proximity to biomass)

GreenEnergyPark™ (Smart biomass - agricultural/forest residues - conversions to energy, chemicals and commercial products)

International Furan Technology (An independent developer and implementer of furfural process technologies)

Connecting-The-Dots™

For the agri (biomass) processing, sugar, pulp&paper, etc. industries, we provide knowhow and technology to convert (residual) biomass to chemicals and energy.

For owners of biomass we offer technology and market access, creating investment opportunities in the cleantech space.

The essential technical challenge facing us, and the world in general, is the complete beneficiation of cellulosic material. We strive to provide viable and practical solution. Contact us to discuss the economic potential of your biomass.
  • Biorefineries
  • Furfural...
Read more ...

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Paid4PreTreatment™: Smart integration of furfural production

In July 2013, we reported on the potential that distiller's grain has for furfural production. The smart integration of furfural production into the mass and energy balance (The-Right-Balance™: in this case of a corn ethanol plant) results in energy savings, an additional saleable product (furfural) and an improved end product (in this case animal feed). These improvements were highlighted by researchers at the University of Wisconsin-Madison (USA) in a process and economic study[1]:

Furfural was produced from DDG while animal feed value of DDG was also retained.

Furfural was produced through dilute acid reaction followed by batch or BRD process.

BRD was superior to batch method in furfural yield and purity.

The economic model predicted an increased profitability for corn ethanol plants.

Animal feed yield was crucial to the economy of the furfural conversion process.

The basis of their economic evaluation is based on assuming favourable inputs (e.g. highest furfural price, best yields, experimental laboratory and mathematical modelling conditions, etc.).

The review of this publication, against our practical furfural processes experience, predicts a lower benefit than the study suggests.

However, it is important to note that there is certainly a benefit (!) and, in addition, there are other untapped downstream revenue potentials.

Also see:

For our clients, we publishes a critical review on this paper and, in our view, a more realistic re-evaluation of this great economic potential.

Biomass for furfural production: Distiller's Grain

Connecting-the-Dots™

Reference:

[1] dx.doi.org/10.1016/j.indcrop.2014.02.025, Co-production of feed and furfural from dried distillers’ grains to improve corn ethanol profitability, Department of Biological Systems Engineering, University of Wisconsin-Madison, WI 53706, United States

  • Furfural
  • Distiller's Grain
  • Feed
  • Corn
  • Maize...

Source:  http://www.dalinyebo.com/index.php?option=com_k2&view=item&id=776:pre-treatment-of-feed-furfural-from-dried-distillers-grains&Itemid=2828

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Paid4PreTreatment™: Smart integration of furfural production

In July 2013, we reported on the potential that distiller's grain has for furfural production. The smart integration of furfural production into the mass and energy balance (The-Right-Balance™: in this case of a corn ethanol plant) results in energy savings, an additional saleable product (furfural) and an improved end product (in this case animal feed). These improvements were highlighted by researchers at the University of Wisconsin-Madison (USA) in a process and economic study[1]:

Furfural was produced from DDG while animal feed value of DDG was also retained.

Furfural was produced through dilute acid reaction followed by batch or BRD process.

BRD was superior to batch method in furfural yield and purity.

The economic model predicted an increased profitability for corn ethanol plants.

Animal feed yield was crucial to the economy of the furfural conversion process.

The basis of their economic evaluation is based on assuming favourable inputs (e.g. highest furfural price, best yields, experimental laboratory and mathematical modelling conditions, etc.).

Our review this publication, against our practical furfural processes experience, predicts a lower benefit than the study suggests.

However, it is important to note that there is certainly a benefit (!) and, in addition, there are other untapped downstream revenue potentials.

Also see:

For our clients, we publishes a critical review on this paper and, in our view, a more realistic re-evaluation of this great economic potential.

Biomass for furfural production: Distiller's Grain

Connecting-the-Dots™

Reference:

[1] dx.doi.org/10.1016/j.indcrop.2014.02.025, Co-production of feed and furfural from dried distillers’ grains to improve corn ethanol profitability, Department of Biological Systems Engineering, University of Wisconsin-Madison, WI 53706, United States

  • Furfural
  • distiller's grain
  • feed
  • corn
  • maize...
Read more ...

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Furfuryl Mercaptan: The good smell of roasted coffee

Although in concentrated form, furfuryl mercaptan is a foul smelling compound. In 1926 it was already patented as coffee’s main odor active compound. It is a furan molecule substituted with a sulfanylmethyl group and is a clear colourless liquid when pure, but it becomes yellow coloured upon prolonged standing.

flavorscientist.com: Furfuryl mercaptan (otherwise known as coffee mercaptan) is the characterizing component of coffee. Coffee flavor and Furfuryl mercaptan are generated by a roasting process and a chemical reaction called the Maillard reaction. The Maillard reaction is one of the most important reactions in food flavor development. The Maillard reaction is between a carbonyl group (sugar) and an amino compound (protein). Degradation of the condensation products of this reaction give a number of oxygenated compounds; such as furans, pyrazines, pyrroles, oxazoles, thiophenes, thiazoles and other heterocyclic compounds.

Furfuryl mercaptan is found in other roasted foods: beef, pork, chicken and popcorn.

coffeechemistry.com: What else is your cup of coffee?

Also see:

Furfural Derivatives in Apple Cider and Wine

The expert panel of FEMA (Flavor and Extract Manufacturers' Association) assessed Furfural as GRAS (generally recognised as safe). More ..

  • Furfural and its many Byproducts
  • coffee
  • Flavour...
Read more ...
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