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Synthesis of the Insecticide Prothrin from 5-(Chloromethyl)furfural (CMF)

J Agric Food Chem. 2014 Jan 3.[1]: Prothrin, a synthetic pyrethroid insecticide, was synthesized from the biomass-derived platform chemical 5-(chloromethyl)furfural in six steps and overall 65% yield. Two structural analogues of prothrin were also prepared following the same synthetic approach. Preliminary testing of these furan-based pyrethroids against the yellow fever mosquito Aedes Aegypti indicates promising insecticidal activities.

CMF is made in a one-step reaction under mild conditons from C6-sugars (e.g. D-fructose, D-glucose, sucrose etc.) or polysaccharides such as cellulose[2].

References:

[1] J Agric Food Chem. 2014 Jan 3

[2] Example: Highly efficient dehydration of carbohydrates to 5-(chloromethyl)furfural (CMF), 5-(hydroxymethyl)furfural (HMF) and levulinic acid by biphasic continuous flow processing, Green Chemistry, Issue 5, 2011 (For our clients: Download publication and supporting information here).

Also see:

Nematicides

Biomass to Pharmaceuticals

From Biomass to Medicines

Since 2001, DalinYebo provides knowhow:

To convert biomass to value added chemical products and applications that are used in industries such as steel, wood, pharmaceutical, automotive, agricultural chemicals, industrial chemicals, etc.

For the agri (biomass) processing, sugar, pulp&paper, etc. industries, we provide knowhow and technology to convert (residual) biomass to chemicals and energy.

For owners of biomass we offer technology and market access, creating investment opportunities in the cleantech space.

The essential technical challenge facing us, and the world in general, is the complete beneficiation of cellulosic material. We strive to provide viable and practical solution. Contact us to discuss the economic potential of your biomass.
  • Furan
  • insecticides
  • Furfural and its many Byproducts...

Lignocellulosic Biomass into a Jet Fuel

A key challenge in the biofuels landscape is to get more advanced biofuels—fuels other than corn ethanol and vegetable oil-based biodiesel—into the transportation pool.

DalinYebo‘s insight:

Furfural has a ±20% higher BTU content than Ethanol! It is a rocket fuel. (dalinyebo.com/biofuels).

See on www.azocleantech.com, via Scoop.itFurfural and its many By-products

 

 ...

Source:  https://dalinyebo.wordpress.com/2014/05/16/lignocellulosic-biomass-into-a-jet-fuel/

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Furan ring is an important pharmacophore in modern drug discovery

Furan, which is made from furfural, is a heterocyclic organic compound, consisting of a five-membered aromatic ring with four carbon atoms and one oxygen. The class of compounds containing such rings are also referred to as furans.

May 2014 - Asian J of Biosciences[1]: Furan a five membered heterocycles has been found with enormous biological activities with the suitable modifications in the structure. The present review is an attempt made to direct the attention of the researchers towards the Furan ring for the development of newer chemical entities. Which are quite useful in the treatment of various life threatening diseases and disorders? Along with the development in the various methods used for the environmentally benign synthesis of Furan with profound biological activities.

.. allow them to interact easily with the biopolymers, possess potential activity with lower toxicities in the chemotherapeutic approach in man.

Reference:

[1] Medworld-asia International Publishers, Asian J of Biosciences, May 2014 (1) 01, 07-14 (For our clients: Download here)

image Asian Journal of Biosciences is an open access, double blind peer revived, bimonthly journal dedicated for publication of high quality research work and unique findings in the field of Biosciences by Medworld - asia .

 

 

 

Also see:

Furfuryl Alginate: Useful for Wound Healing

Biomass to Pharmaceuticals

From Biomass to Medicines

Connecting-The-Dots™

From Biomass to Value Added Products (Pharmaceutical, Ag-chemicals, Industrial Chemicals, etc.)

For the agri (biomass) processing, sugar, pulp&paper, etc. industries, we provide knowhow and technology to convert (residual) biomass to chemicals and energy.

For owners of biomass we offer technology and market access, creating investment opportunities in the cleantech space.

The essential technical challenge facing us, and the world in general, is the complete beneficiation of cellulosic material. We strive to provide viable and practical solution. Contact us to discuss the economic potential of your biomass.
  • Furfural
  • Furan
  • medical
  • pharmaceutical...

Bioenergy Crops Could Become Invasive Species

While some crops could hold great potential as bioenergy sources, they could also pose a threat as an invasive species. A new study in the journal Invasive Plant Science and Management says that a …

DalinYebo‘s insight:

This also applies for Africa!

That is why DalinYebo works with African plant breeders and farmers, in order to provide sustainable and environmentally correct solutions that go beyond the process technology.

See on domesticfuel.com

via  Scoop.itFurfural and its many By-products...

Source:  https://dalinyebo.wordpress.com/2014/04/11/bioenergy-crops-could-become-invasive-species/

Analysis of biodegradation performance of furfural and 5-hydroxymethylfurfural

Furfural and 5-hydroxymethylfurfural (HMF) are the degradation products of lignocellulose during pretreatment operations and significantly inhibit the consequent enzymatic hydrolysis and fermentation processes. The biodetoxification fungus Amorphotheca resinae ZN1 had demonstrated its excellent capacity on degrading lignocellulose derived inhibitors and helped the fermentation processes to achieve high yield of ethanol and biochemicals …

DalinYebo‘s insight:

Provided the furfuryl/HMF alcohols can be recovered economically, this process may add another pathway to furfural chemistry.

* Alternatively, there are conventional and other new technologies available that are suitable alternatives to detoxify fermentation inhibitors, as described in http://pubs.rsc.org/en/content/articlelanding/2014/ra/c3ra43512a.

Example for the uses of the furfural chemistry: http://blog.dalinyebo.com/green-pet-bottles-from-furfural

See on 7thspace.com

via See on Scoop.itFurfural and its many By-products

 

 ...

Source:  https://dalinyebo.wordpress.com/2014/04/11/analysis-of-biodegradation-performance-of-furfural-and-5-hydroxymethylfurfural/

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